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Beyond the Amplitude Project

In January 2020 the AMPLITUDE project set out with the ambition of developing and testing new technologies that advance bladder cancer diagnosis and treatment by utilizing the third biological window for deeper, high-resolution tissue imaging.  


With funding from the Horizon 2020, research and innovation program, the AMPLITUDE team designed and manufactured prototype devices including:  

  • A compact and cost effective ultrashort pulsed laser with tunable operation between 1650 and 1700nm and integrated frequency mixing for second harmonic generation at 837nm.  

  • An upright multi-photon microscope unifying metabolic, morphological and molecular imaging capabilities in one device and support image acquisition at 1675nm and 837nm. 

  • A multimodal endoscopic probe optimised to operate in the third biological window and capture high resolution non-linear images in thick tissues.  


In late 2024, the laser was incorporated into a multi-modal microscopy setup at the ICFO - Institut de Ciencies Fotoniques to evaluate the system's capabilities. This testing highlighted the potential of utilizing the third biological window for deeper tissue imaging, achieving penetration depths of over 1mm. This performance marks a significant enhancement compared to shorter wavelengths.


Although this is an encouraging outcome, additional research is necessary to evaluate the application of the 1675nm microscope for detecting and distinguishing various grades and stages of bladder cancer in excised biopsies. The clinical team at Amplitude, University of Florence, Italy, has undertaken this challenge and is currently conducting proof-of-concept tests with the microscope. Their objective is to demonstrate that Amplitude imaging systems can enhance the diagnosis and monitoring of bladder cancer. We eagerly anticipate their findings.



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© Amplitude Project 2020 

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 871277

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