Amplitude targeted the development of new multimodal imaging systems exploiting novel laser sources and state-of-the-art imaging and spectroscopic technologies to fulfil unmet clinical needs in terms of the specificity and accuracy of cancer diagnosis and therapy monitoring.
The project exploited currently unavailable wavelengths, and used them for high resolution non-linear imaging and confocal microscopy to capture deeper morphological and structural information about biological tissues and combined this with the functional/molecular information provided by metabolic imaging and Raman spectroscopy to produce technologies that offer a holistic picture of the condition and functioning of the tissue.
The Amplitude Technologies
The Amplitude technologies include prototypes of novel ultrafast lasers that access currently unavailable wavelengths and real-time high-resolution imaging systems
1675nm Laser
The Amplitude laser is an ultrashort pulsed high-power fibre laser operating between 1650-1720 nm delivering at least 150 fs and 100 mW of average power. The laser is a reliable, flexible, and compact source with excellent beam quality and waveguide structure. Highly efficient and powerful gain materials mean high peak power can be realised in a compact and low-cost setup.
Multi-modal Microscope
The Amplitude microscope is a turnkey solution based on the Femtonics SMART microscope family which is an upright two-photon microscope. The optics and formulation of the Amplitude systems have however been updated to unify metabolic, morphological and molecular imaging capabilities in one device and support image acquisition at 1675nm and 837nm.
Endoscopic Probe
The Amplitude multimodal endoscopic probe is designed to to operate in the third biological window (1675nm) and offers the potential to image deeper into tissue. The device is anticipated to be used for real-time margin assessment and tumour grading and staging during resection and to guide conventional biopsy procedures.
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